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  • Allosteric communication in DNA polymerase clamp …

    How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

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  • Faculty Research Page | Molecular and Cell Biology

    Feb 06, 2019 · DNA Polymerase Clamp Loaders: Highly processive DNA polymerases are tethered to ring-shaped sliding clamps that encircle DNA, allowing rapid movement of the replication fork (Kelch et al., 2012). Over two decades, I worked with Mike O'Donnell (Rockefeller University) to establish the structural principles underlying the clamp-loader complexes

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  • TFE and Spt4/5 open and close the RNA polymerase clamp

    Mar 29, 2016 · DNA-dependent RNA polymerases (RNAPs) are complex enzymes that synthesize RNA in a factor-dependent fashion. Like mechanical engines, RNAPs consist of rigid and flexible parts; the catalytic function of RNAPs critically relies on conformational changes. Based on single-molecule FRET measurements that directly report on the movements of the RNAP clamp of the archaeal 12-subunit …

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  • (PDF) Structural and enzymatic studies of the T4 DNA

    Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction Loading of the phage T4 sliding clamp gp45 by the gp44/62 clamp loader onto DNA to form

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  • Plant DNA polymerases α and δ - Nature Communications

    May 13, 2021 · In yeast and mammalian cells, the translesion DNA polymerase ζ shares two regulatory subunits with DNA polymerase δ, namely POLD2 and POLD3 25,26.In order to …

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  • Bobcat vs John Deere Skid Steer Loader: What's the

    Nov 29, 2020 · Bobcat skid steers offer some great features such as automatic ride control and a hydrostatic pump. These make the skid steers easier to use smoothly with minimal spillage. Between the high-quality of the skid steer and the number of available attachments, you can be certain that you will be happy with your Bobcat. John Deere.

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  • Fluorometric Assay for DNA Polymerases and Reverse

    Aug 02, 2018 · Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction 13 April 2021 | eLife, Vol. 10 Engineering …

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  • Starter -Bobcat Skid Steer Loader S175, S185, S250

    Shop for the Starter For Bobcat Skid Steer Loader S175, S185, S250 DSL6676957; 410-40014 at DB Electrical. The best selection, low prices, fast shipping, and great customer service.

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  • Pfam: Family: DNA_pol_A (PF00476)

    Pfu DNA polymerase is a heat-stable enzyme of this family found in the hyperthermophilic archaeon Pyrococcus furiosus. Detailed classification divides family B in archaea into B1, B2, B3, in which B2 is a group of pseudoenzymes. Pfu belongs to family B3. Others PolBs found in archaea are part of "Casposons", Cas1 -dependent transposons.

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  • Bobcat 753 Skid Steer Loader won't start just makes a

    Dec 02, 2014 · Bobcat 753 Skid Steer Loader won't start just makes a clicking noise - Answered by a verified Mechanic We use cookies to give you the best possible experience on our website. By continuing to use this site you consent to the use of cookies on your device as described in our cookie policy unless you have disabled them.

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  • 6685191 | Starter Assembly for Bobcat® Skid Steer Loader

    Description. Starter Motor Assembly for Bobcat® Skid Steer. This is the Starter Assembly Only. ( High Quality 12 Volt Industrial Starter ) 9 Teeth. Fits Skid Steer Brand: Bobcat®. Select Bobcat® Select Model and Serial Number Above. Product Details. Brand.

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  • Molecular Biology Topics

    Nov 09, 2021 · Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction. Elife. 2021 Apr 13;10:e66181. Skalenko KS, Li L, Zhang Y, Vvedenskaya IO, Winkelman JT, Cope AL, Taylor DM, Shah P, Ebright RH, Kinney JB, Zhang Y, Nickels BE.

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  • Allosteric communication in DNA polymerase clamp …

    How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

    Learn More
  • Allosteric communication in DNA polymerase clamp …

    Apr 13, 2021 · Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction | eLife. Deep mutagenesis of a clamp-loader complex reveals a critical hydrogen-bonded junction that is important for allosteric communication in oligomeric AAA+ ATPases. Skip to Content. eLife home page.

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  • Crystal structure of the processivity clamp loader gamma

    Aug 01, 2001 · Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction. Subramanian S, Gorday K, Marcus K, Orellana MR, Ren P, Luo XR, O'Donnell ME, Kuriyan J. Elife, 10, 13 Apr 2021 Cited by: 0 articles | PMID: 33847559 | PMCID: PMC8121543. Free to read & use

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  • TFE and Spt4/5 open and close the RNA polymerase clamp

    Mar 29, 2016 · DNA-dependent RNA polymerases (RNAPs) are complex enzymes that synthesize RNA in a factor-dependent fashion. Like mechanical engines, RNAPs consist of rigid and flexible parts; the catalytic function of RNAPs critically relies on conformational changes. Based on single-molecule FRET measurements that directly report on the movements of the RNAP clamp of the archaeal 12-subunit …

    Learn More
  • DNA polymerase - Wikipedia

    DNA polymerase's ability to slide along the DNA template allows increased processivity. There is a dramatic increase in processivity at the replication fork. This increase is facilitated by the DNA polymerase's association with proteins known as the sliding DNA clamp. The clamps are multiple protein subunits associated in the shape of a ring.

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  • Allosteric communication in DNA polymerase clamp loaders

    How a DNA Polymerase Clamp Loader Opens a Sliding Clamp

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  • Allosteric regulation of the primase (DnaG) activity by

    Given the prominent structural role of τ in the clamp-loader as well as the interaction of the clamp-loader with DnaB and the core polymerase via τ, and with the SSB via χ (Kelman et al., 1998; Glover and McHenry, 1998; Witte et al., 2003), it is important to reveal whether allosteric events mediated by macromolecular interactions within the

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  • Crystal structure of the processivity clamp loader gamma

    Aug 01, 2001 · Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction. Subramanian S, Gorday K, Marcus K, Orellana MR, Ren P, Luo XR, O'Donnell ME, Kuriyan J. Elife, 10, 13 Apr 2021 Cited by: 0 articles | PMID: 33847559 | PMCID: PMC8121543. Free to read & use

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